Research


A father’s crusade in rare disease drug development: a case study of Elpida therapeutics and Melpida

Portero, Deanna, Qingyang Xu, Aaliya Hussain, and Andrew W. Lo (2025), A Father’s Crusade in Rare Disease Drug Development: A Case Study of Elpida Therapeutics and Melpida, Orphanet Journal of Rare Diseases 20, https://doi.org/10.1186/s13023-025-03892-0.

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Financing Drug Development via Adaptive Platform Trials

Cho, Joonhyuk, Eugene Sorets, Shomesh Chaudhuri, Annette De Mattos, Kristin Drake, Merit E. Cudkowicz, Ricardo Ortiz, Meredith Hasenoehrl, Marianne Chase, Brittney Harkey, Sabrina Paganoni, and John Frishkopf (2025), Financing Drug Development via Adaptive Platform Trials, PLoS ONE 20 (7), e0325826, https://doi.org/10.1371/journal.pone.0325826.

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Predicting Clinical Trial Duration via Statistical and Machine Learning Models

Cho, Joonhyuk, Qingyang Xu, Chi Heem Wong, and Andrew W. Lo (2025), Predicting clinical trial duration via statistical and machine learning models 45, 101473. https://doi.org/10.1016/j.conctc.2025.101473.

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The Evolution of Discrimination: How Finite Memory Shape Population Behavior? (Working Paper)

Lo, Andrew W., Ruixun Zhang, and Chaoyi Zhao (2025), The Evolution of Discrimination: How Finite Memory Shape Population Behavior?, Working Paper.

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Applications of Portfolio Theory to Accelerating Biomedical Innovation

Kumar, Neil, Andrew W. Lo, Chinmay Shukla, and Brian Stephenson (2024), Applications of Portfolio Theory to Accelerating Biomedical Innovation, Journal of Portfolio Management 51 (1), 213-236.

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Innovative Insurance to Improve US Patient Access to Cell and Gene Therapy

Conti, Rena M., Patrick DeMartino, Jonathan Gruber, Andrew W. Lo, Yutong Sun, and Jackie Wu (2025), Innovative Insurance to Improve US Patient Access to Cell and Gene Therapy, The Milbank Quarterly 103 (1), 32-51, https://doi.org/10.1111/1468-0009.12728.

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Performance Attribution for Portfolio Constraints

Lo, Andrew W., and Ruixun Zhang (2024), Performance Attribution for Portfolio Constraints, Management Science, https://doi.org/10.1287/mnsc.2024.05365.

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Quantifying the Returns of ESG Investing: An Empirical Analysis with Six ESG Metrics

Berg, Florian, Andrew W. Lo, Roberto Rigobon, Manish Singh, and Ruixun Zhang (2024), Quantifying the Returns of ESG Investing: An Empirical Analysis with Six ESG Metrics, Journal of Portfolio Management 50 (8), 216–238.

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Can ChatGPT Plan Your Retirement?: Generative AI and Financial Advice

Lo, Andrew W., and Jillian Ross (2024), Can ChatGPT Plan Your Retirement?: Generative AI and Financial Advice, Harvard Data Science Review (Special Issue 5), https://doi.org/10.1162/99608f92.ec74a002.

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A Review of Economic Issues for Gene-Targeted Therapies: Value, Affordability, and Access

Garrison, Louis P., Andrew W. Lo, Richard S. Finkel, and Patricia A. Deverka (2023), A Review of Economic Issues for Gene-Targeted Therapies: Value, Affordability, and Access, American Journal of Medical Genetics Part C: Seminars in Medical Genetics 193 (1), 64–76.

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